Researchers Develop Drug-like Molecules To Improve Schizophrenia Treatment

In a transaction announced this week, Vanderbilt has certified the compounds to Karuna Pharmaceuticals in Boston, Mass., for further development leading to human testing. The brand new Vanderbilt substances work in different ways than existing medications fundamentally, by inhibiting glycine transporter one (GlyT1), an action which allows to get more normal function of brain cells involved with schizophrenia.

“The potential of the new substances to ameliorate the damaging cultural and cognitive deficits of schizophrenia, which do not respond to available medications currently, is very thrilling,” said National Institute of Mental Health (NIMH) Director Thomas R. Insel, M.D. The novel compounds were developed by Jeffrey Conn, Ph.D., and Craig Lindsley, Ph.D., co-directors of the Vanderbilt Center for Neuroscience Drug Discovery (VCNDD), and their co-workers in the VCNDD, part of Vanderbilt University Medical Center.

Schizophrenia is a chronic disabling mental illness that affects more than 3 million Americans according to the NIMH, and 24 million people worldwide, based on the World Health Organization. 20 billion a year. 10 million grant to establish a National Cooperative Drug Development and Discovery Group, targeting new schizophrenia therapies. The work is now sufficiently much enough along to hand off to Karuna Pharmaceuticals, a Boston- based company centered on developing breakthrough remedies for schizophrenia.

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